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Magnetic Resonance Spectroscopy (MRS)
Proton MRS allows non-invasive quantification of muscle metabolites, such as lipids, total creatine, and choline. Using this methodology, we are capable of differentiating and selectively measuring lipids located inside or in between muscle cells. This technique has been widely employed as a surrogate marker for insulin sensitivity in studies examining type 2 diabetics, obese and HIV-lipodystrophy patients.
Our MRS data is acquired on GE or Siemens scanners at 1.5T or 3.0T field strengths, and is analyzed with validated softwares such as LCModel and jMRUI.
We can modify or develop MRS acquisition protocols in order to address your specific clinical endpoint. Please contact us for further information
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Proton MRS spectrum of tibialis anterior muscle with peak fitting using LCModel (dark trace, fitted spectrum; thin trace, raw data; thin trace in top of figure, residual). [1] IMCL (-CH3), intramyocellular lipid methyl protons at 0.9 ppm [2] EMCL (-CH3), extramyocellular lipid methyl protons at 1.1 ppm [3] IMCL (-CH2), intramyocellular lipid methylene protons at 1.3 ppm [4] EMCL (-CH2), extramyocellular lipid methylene protons at 1.5 ppm [5] TCr, total creatine (-CH3) resonance at 3.0 ppm [6] TMA, trimethylamines, choline peak at 3.2 ppm |
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